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Selasa, 28 Juni 2016

Creatine Uptake, Bioavailability, and Efficacy - We've Gotten it all Wrong and Low Serum Creatine Levels are Better!?

If you put some faith into the marketing campaigns of supp producers, there's a creatine for everyone: one to get lean, one to get strong and one to get big and buffed... bullocks!
It has been a while since I've discussed the bioavailability of different forms of creatine. On various supplement sites, the notion that there was one form of creatine that was significantly more bioavailable and would thus allow you to 'load' muscle phosphocreatine (PCr) faster and more efficiently is obviously still a matter of constant debate... a debate of which the latest study by Ralf Jäger et al. (2016) indicates that it may argue based on a fundamentally flawed premise, i.e. that higher serum levels of creatine after the ingestion of a given product would signify an increased efficacy in terms of performance / strength / size gains.

How come? Well, the previously mentioned, as of yet unpublished data from a study by Ralf Jäger, Martin Purpura, and Roger C Harris did not just confirm the results of previous studies, which indicate that glucose (75g) and alpha lipoic acid (ALA | 200mg) will increase the bioavailability of creatine, i.e. "the proportion of a drug or other substance [in this case creatine] that enters the circulation when introduced into the body" (Merriam-Webster.com), it also indicates that the practically relevant predictor of creatine's efficacy is - assuming equal dosing and complete absorption - not a high, but rather a low level of creatine in the blood.
You can learn more about creatine at the SuppVersity

Creatine Doubles 'Ur GainZ!

Creatine Loading = Unnecessary

Creatine Pre or After Workouts?

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Creatine Blunts Fat Loss?

Build 'Ur Own Buffered Creatine
What? Let me explain: Initially, it may be worth pointing out that we are talking about a small scale study the results of which have not yet been published in the peer-reviewed journal. In that study, Jäger et al. aimed to compare the effects of ingesting tricreatine citrate (5g, TCrC),
  • in combination with 75g of glucose and 200mg of alpha-lipoic acid, or
  • without the former bioavailability enhancers.
on only six subjects. These three men and three women (35.5+/-14.5 yrs, 172.5+/-12.2 cm, 75.3+/-9.0 kg), who were all healthy, normal-weight and non-vegetarian and thus not, with creatine being a deficiency nutrient in vegetarians, extraordinarily susceptible to creatine supplementation (Burke. 2003), participated in two testing sessions during which they received the previously explained two treatments (the powdered supplements were simply dissolved in 450 ml of water).
Adding carbohydrates or cinnamon to creatine may well increase its uptake to the muscle. What it does not do, however, is to enhance creatine's efficacy - at least not in a 2015 3-week creatine loading study Islam et al. conducted in 25 recreational gymrats.
What's the increased absorption worth? If we rely on a a recent study by Islam, et al. (2015) the answer is (unfortunately) nothing. In their 2015 study, the scientists from the Wilfrid Laurier University and the University of Lethbridge in Canada found no (=zero) significant differences in anaerobic power, strength, and endurance when creatine was administered solo, with the same 70 g carbohydrate (CHO) that were used in Jäger et al. (2016), or 500 mg cinnamon extract (CIN), of which the authors believed that its proven ability to improve insulin sensitivity and up-regulate glucose transport in skeletal muscle would likewise enhance the uptake of creatine in the muscle and thus make it more effective.
With their cross-over after the initial test and a 7 day break between the tests, the scientists would have been able to compare the effect of adding glucose and alpha lipoic acid to the tricreatine citrate (Creapure™ Citrate, AlzChem, Trostberg, Germany | 65% w/w creatine) on an individual level. Corresponding data, however, is not (yet?) available. Instead, we get the likewise interesting statistical averages (see Figure 1):
Figure 1: Mean plasma creatine concentration over 8 hours following ingestion of 5g tricreatine citrate (TCrC) and 5g tricreatine citrate + 75g glucose + 200mg alpha-lipoic acid (TCrC+Glu+ALA | Jäger. 2016).
And these data present a quite intriguing result. More specifically, they indicate that the increase in peak concentration and the area under the curve (indicative of the total amount of creatine that appeared in the blood of the subjects) were significantly lower in the TCrC+Glu+ALA group in comparison to TCrC (75.3%, p<0.05, and 82.2% respectively).

Less creatine in the blood with sugar + ALA? That's bad, right? No that's good!

Just as the likewise lower 0.5 and 1h plasma concentrations of creatine, in the TCrC+Glu+ALA group (in comparison to TCrC), these reductions do not indicate a reduced efficacy of the supplement. On the contrary! The significantly elevated mean 8h urinary creatine elimination in the control group (TCrC | 26.5 ± 13.9% of the dose administered  vs. 17.2 ± 13.0% for TCrC+Glu+Ala) rather indicates that the addition of glucose and ALA "enhanced rate of creatine uptake into the muscle" - as previous studies indicate probably due to the presence of raised insulin (by glucose) and / or an increased insulin sensitivity (by ALA / Koszalka. 1972; Steenge. 1998; Pittas. 2010).
Figure 2: The study on creatine + glucose and creatine + cinammon by Islam et al. (red box) is not the only one that shows that the increased deposition of creatine in the muscle doesn't give you athletic advantages. The exact same results have been observed in an 8-week study comparing 70 g of a dextrose placebo (PL), 5 g creatine/70 g of dextrose (CRD) or 3.5 g creatine/900 mg fenugreek extract (CRF) by Taylor et al. (2011)
Why's this study relevant? Well, the answer should be obvious. The few allegedly 'advanced creatine products' on the market that actually have scientific back-up of their efficacy often refer to studies showing increases in plasma creatine of which the study at hand shows that they are no valid predictor of the actual efficacy of the supplement. The latter obviously depends on muscle creatine uptake, not serum peak levels or AUC. Don't be a fool, though: This does not mean that lower serum levels after ingestion were automatically better. After all, those lower levels of creatine in the blood may well be a mere result of an impaired / incomplete absorption in the gut.

Confusing? Well, let's summarize: By measuring the creatine level in the blood and the excretion of creatine in urine, Jäger et al. were able to refute the (ostensibly) logical assumption that higher serum creatine levels would indicate an improved efficacy. What they did not prove conclusively, however, is that the creatine levels in the muscle were in fact significantly higher (no biopsies) and, most importantly, that this makes a performance difference. The latter has after all been refuted in previous studies, such as Islam et al. (2015 | see red box and Figure 2). The hunt for the "best form" of creatine will thus probably go on, albeit with different experimental means, i.e. either the measurement of serum and urinary creatine as it was done in the study at hand or (even better) the direct assessment of muscle creatine stores and the actual performance benefits | Comment!
References:
  • Burke, Darren G., et al. "Effect of creatine and weight training on muscle creatine and performance in vegetarians." Medicine and science in sports and exercise 35.11 (2003): 1946-1955.
  • Jäger, Ralf, Martin Purpura and Roger C Harris. "Reduction of Plasma Creatine Concentrations as an Indicator of Improved Bioavailability." Upublished data from privatt conversation (2016).
  • Koszalka, Thomas R., and Carole L. Andrew. "Effect of insulin on the uptake of creatine-1-14C by skeletal muscle in normal and X-irradiated rats." Experimental Biology and Medicine 139.4 (1972): 1265-1271.
  • Pittas, G., et al. "Optimization of insulin-mediated creatine retention during creatine feeding in humans." Journal of sports sciences 28.1 (2010): 67-74.
  • Steenge, G. R., et al. "Stimulatory effect of insulin on creatine accumulation in human skeletal muscle." American Journal of Physiology-Endocrinology And Metabolism 275.6 (1998): E974-E979.
  • Taylor, Lem, et al. "Effects of combined creatine plus fenugreek extract vs. creatine plus carbohydrate supplementation on resistance training adaptations." Journal of sports science & medicine 10.2 (2011): 254.

Minggu, 26 Juni 2016

Strength Plateau? Try Daily Changing Loads: In Advanced Trainees, A, B, C-Days W/ 15, 10, 5 Reps at 70, 80, 90% 1RM Boost 6-Week Strength Gains on All Major Lifts by ~40%

DCL, i.e. using daily changing loards worked for both, men and women.
The object of today's SuppVersity article comes almost from around the corner: a study conducted by Christoph Eifler, a scientist from the Department of Applied Training Science at the German University of Applied Sciences for Prevention and Health Management (DHfPG) in Saarbrücken (Germany) that is supposed to provide "evidence based training recommendations to the 8.55 million recreational athletes [who] perform fitness-related resistance training in German [gyms]" (Eifler. 2016) - advice that's valid for US boys & girls, Frenchmen & -women and even the Brexiters, too ;-)

As the relatively unspectacular abstract says, "[t]he purpose of this investigation was to analyze the short-term effects of different loading schemes in fitness-related resistance training and to identify the most effective loading method for advanced recreational athletes" (Eifler. 2016)... not exactly something other studies hadn't done before, right? Well, I agree, but...
Learn more about training for "gainz" in both strength and size...

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Not only was the study "designed as a longitudinal field-test study", it also included two hundred healthy mature subjects with at least 12 months experience in resistance training and 4 groups of 50 subjects, each (equal gender distribution), who were randomly assigned to train according to the following four load-schemes for six weeks (see Table 1 for a detailed breakdown):
  • constant load (CL) with constant volume of repetitions, 
  • increasing load (IL) with decreasing volume of repetitions, 
  • decreasing load (DL) with increasing volume of repetitions, 
  • daily changing load (DCL), and volume of repetitions 
As Eifel highlights, "[a]ll participants performed a standardized resistance training protocol" which comprised an entire resistance training protocol with 8 resistance training exercises for different muscle groups in a systematic and standardized order.
Table 1: Study design: constant and variable loading parameters | *TS = training session; CL = constant load; IL = increasing load; DL = decreasing load; DCL = daily changing load; 1RM = 1 repetition maximum (Eifel. 2016).
Exercise collocation and exercise order in pretest, posttest, and training period were, as Eifel highlights, chosen to be "representative as possible for a recreational resistance training program at commercial fitness clubs" (Eifel. 2016).
Where's the DEXA scanner? That's exactly the question Eifler probably asked himself when he did this field study... all jokes aside: Germany is a rich country, but we still don't have a DEXA at each gym. This is why "[i]n this investigation, training effects were exclusively quantified by testing strength performance (10RM, 1RM)", even though the author knows that "[m]ost clients of a commercial fitness club perform resistance training for preventive or aesthetic aspects" (Eifler. 2016). Ah,... and before you start complaining, I should remind you of the number and training experience of the subjects: N=200 advanced trainees - that gives the study an almost unique statistical power and high practical relevance for trainees like you and me.
More specifically, both, in testing and training, the following resistance training exercises were performed (in the given order): horizontal leg press, chest press, butterfly, lat pull-down, horizontal row, dumbbell shoulder press, cable triceps push-downs, and dumbbell biceps curls - all done on standard gym equipment from various manufacturers (Gym80, Technogym, Lifefitness, Panatta, Nautilus, Precor, David, Schnell, MedX by Delphex, Cybex, Ergofit, and Matrix) and/or with customary dumbbells.
Figure 1: Cumulated effect sizes (Cohen’s d) in 10RM & 1RM (Eifel. 2016); %-ages = rel. difference to DCL | * p < 0.05 for DCL vs. DL and IL & p < 0.001 for DCL vs. CL; p < 0.001 for the mean difference of DCL vs. others (Eifel. 2016).
Unsurprisingly, significant effects on muscle strength gains (p < 0.001) "could be noted for all resistance training exercises" (Eifel. 2016). What may not be that self-evident, on the other hand, is that Eifel also observed significant inter-group differences for both dependent variables (10RM, 1RM), with daily changing load (DCL, EDIT of which I previously falsely claimed that it was fundamentally different from undulating periodization, as it was assessed in e.g. Foschini. 2010; Monteiro. 2009; Rhea. 2002; Simão. 2012 - it's obviously the same, but with the order of the three workouts being reversed every week) in which the analysis of the effect sizes indicates "significantly higher strength gains (p < 0.001) than CL, IL, and DL.

It is furthermore worth mentioning that a comparison of constant, increased and decreasing load patterns did not yield any statistically significant differences. This is likewise an important result, because it explains why most previous studies indicate that changing the load scheme will not significantly affect the performance outcomes of resistance training protocols. After all, said studies mostly lacked a DCL scheme, i.e. a training program in which the loading patterns changed according to Table 1 on a daily basis (or rather from session to session).
Another alternative to try is classic pyramid training, I suggest that you (re-)read my 2012 article "Up & Down The Rack: Study Compares Strength & Size Gains from Good Old Double-Pyramid and Reverse Loading" which discusses a study that confirms its efficacy and suggests that especially the thighs will benefit.
"No gainz, bro?" I am quite certain that there were muscle gains in all subjects. They were just not evaluated in the study at hand (cf. red box). With that being said, the evidence that "resistance training following DCL is more effective for advanced recreational athletes than CL, IL, or DL" (Eifel. 2016), is conclusive enough to assume a similar advantage will exist for other study outcomes, including your beloved "gainz". After all, this well-powered study leaves no doubt that with DCL, which "is widely unknown in fitness-related resistance training", there's "potential for improving resistance training in commercial fitness clubs" (Eifel. 2016) - and let's be honest: isn't training w/ different reps / intensities sets (increasing load) on each workout and reversing the order of the days every week also more fun than classic linear periodization? Comment!
References:
  • Foschini, Denis, et al. "Treatment of obese adolescents: the influence of periodization models and ACE genotype." Obesity 18.4 (2010): 766-772.
  • Eifler, C. Short-term effects of different loading schemes in fitness-related resistance training. J Strength Cond Res 30(7): 1880–1889, 2016
  • Monteiro, Artur G., et al. "Nonlinear periodization maximizes strength gains in split resistance training routines." The Journal of Strength & Conditioning Research 23.4 (2009): 1321-1326.
  • Rhea, Matthew R., et al. "A comparison of linear and daily undulating periodized programs with equated volume and intensity for strength." The Journal of strength & conditioning research 16.2 (2002): 250-255.
  • Simão, Roberto, et al. "Comparison between nonlinear and linear periodized resistance training: hypertrophic and strength effects." The Journal of strength & conditioning research 26.5 (2012): 1389-1395.

Selasa, 10 Mei 2016

Accentuated Eccentric, Extra-Ordinary Gains - Benefits are Exuberant Compared to Trained Subjects' Own Split-Routine

Single-arm dumbbell curls are unquestionably the exercise people will do most frequently with accentuated eccentrics and supra-maximal loads. Unfortunately, the study at hand used only leg exercises. So no information about arm-development, here..
As a very recent paper in Frontiers in Physiology rightly point out, "it becomes more challenging to induce further neuromuscular [...], as training experience increases adaptation" (Walker. 2016). When you are hitting a plateau, the only promising option, according to the authors is to seek "alternative training methods in order to further increase strength and muscle mass" (ibid.).
One of the classic methods to do just that is to utilize accentuated eccentric loading, i.e. to apply a greater external load during the eccentric phase of the lift as compared to the concentric phase (e.g. doing concentration curls with a supra-maximal weight, using the free arm to lift the weight up and only the working arm to slowly lower it, afterwards).
Are you looking for muscle builders for the year 2016? Find inspiration in these articles:

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Study Indicates Cut the Volume Make the Gains!
In the twin-control group design study, Walker et al. conducted with thirty-three healthy young men had the subjects with 2-7 years of training experience either...
  • switched to an accentuated eccentric load-training (AEL),
  • continued on the classic split-training routine they were doing, anyway (CON), or
  • followed a traditional concentric-eccentric isoinertial training program (TRAD).
While the subjects in the CON group were not supervised and didn't have the same strict dietary control, subjects in the AEL and TRAD groups received the same strick ksupervision and were subjects to the same dietary conditions - the real control group is thus not the CON, but the TRAD group, "because subjects are exposed to the same study conditions as the experimental group. The AEL group performed the same training as TRAD but used greater loading during the eccentric phase, as described in detail below" (Walker. 2016). Speaking of which:
TRAD and AEL engaged in two 5-week training periods where training was performed twice a week(Monday and Thursday or Tuesday and Friday, to allow at least 48 h recovery between training sessions). Training consisted of three sets of 6-RM (session 1) and 10-RM (session 2) bilateral leg press and unilateral knee extension and flexion exercises. [...] TRAD performed the exercises with the same load for both concentric and eccentric phases, while AEL performed the exercises with 40% greater load during the eccentric phase compared to the concentric phase (i.e. eccentric load = concentric load + 40%) [...] In order for each training session to include a true RM, both TRAD and AEL used loads that elicited concentric failure in at least 1 out of 3 sets with the investigator assisting the subject to complete the set. 
Figure 2: Illustration of how weight-releasers were used to add add. load on eccentrics  (Walker. 2016).
Custom weight-releasers were used to add the additional eccentric load to the leg press exercise (Figure 1, left) while weight plates were manually added and removed by the training supervisor(s) with the use of a custom-built pin for the knee extension exercise (Figure 1, right). Both groups performed the concentric and eccentric phases of the lift with a 2:2 s tempo (i.e. 4 s in total), which was monitored by the investigator" (Walker. 2016).
Immediately after each training session TRAD and AEL subjects were given a standardized recovery drink containing 23 g of whey protein (8.47 g leucine and 5.08 g isoleucine per 100 g), 3 g of carbohydrate and 1.6 g of fat (Total+, Vital Strength, PowerFoods International Pty Ltd, Marrickville, New South Wales, Australia) to maximize the initial protein synthesis response to training and standardize post-exercise nutrition between groups.
Figure 2: Overview of changes in performance markers (absolute, left; rel. right | Walker. 2016).
In spite of the identical nutrition and supplementation regimen and the highly similar workout protocols, the maximum isometric torque of the subjects in the AEL group increased significantly more in the accentuated eccentric load group than control (18±10% vs. 1±5%, p<0.01) over whole 10 week study - this benefit was accompanied by, or maybe even facilitated by an increase in voluntary activation (3.5±5%, p<0.05) the scientists analyzed by the means of EMG electrodes.
Figure 3: Changes in volunatary activation level (%) in the three study groups (Walker. 2016).
The study also shows that the eccentric (AEL) regimen lead to sign. increases of the isokinetic eccentric torque (10±9%, p<0.05), while the TRAD group saw only increases concentric torque - increases that were albeit smaller (9±6%; p<0.01 vs. 10±9%; p<0.01; difference 1±7%; p<0.05) than those of the AEL group. And even the knee extension repetition-to-failure improved in the accentuated eccentric load group only (28%, p<0.05). Against that background it is a bit surprising that the authors found "similar increases in muscle mass occurred in both intervention groups" (Walker. 2016).
While there was no difference between the size gains in the TRAD and AEL groups, meaning that eccentric training did not promote muscle gains, both forms of training were vastly superior to the subjects' individual routines (CON).
Bottom line: "In summary, accentuated eccentric load training led to greater increases in maximum force production, work capacity and muscle activation, but not muscle hypertrophy, in strength-trained individuals" (Walker. 2016).

The above is the indisputable conclusion to an interesting study which also shows that either changing your training or stop training like a bro (i.e. according to your own often over-crowded split routine, like subjects in CON) will yield gains in strength and size you'd never seen if you continued on the same stamped out paths you've been pursuing for years. Compared to the effect of this change the add. benefits of eccentric loading are small | Comment!
References:
  • Walker, Simon, et al. "Greater strength gains after training with accentuated eccentric than traditional isoinertial loading loads in already strength-trained men." Frontiers in Physiology 7 (2016): 149.

Kamis, 28 April 2016

Breakdown aka Drop-Sets, Another Very Popular Advanced Training Technique W/Out Sign. Adaptational Advantages?!

"There are some crossovers between size training and strength training, and using drop-sets and ladder sets will definitely give some benefit ...," this is what you can read on the Internet, but is that true?
In view of the fact that resistance training (RT) leading to momentary muscular failure (MMF) has been evidenced as producing significantly greater muscular strength and hypertrophic adaptations when compared with RT not performed to MMF in various studies (Fisher. 2011 & 13), the assumption that techniques that promote the occurrence of MMF and the subsequent increased recruitment of motor units (MUs) and muscle fibers (Henneman’s size principle | Carpinelli. 2008; Jungblut. 2009) would produce increased muscular strength and size gains is only logical.

In spite of the existing evidence that training to MMF seems to be important for optimizing adaptations, the use of advanced RT techniques that allow a trainee to potentially train beyond failure, has yielded worse than 'mixed' results.
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The latter goes for techniques, such as rest-pause (Giessing. 2014) and pre-exhaustion (Fisher. 2015), as well as using supra-physiological loads - all of them didn't show the benefits scientists had hoped for based on their ability to train to full or eve past MMF.

In a recent study, Fisher et al. did now investigate another commonly used intensity / advanced training tequnite: breakdown (BD) aka  drop sets o descending (Ogborn. 2014; Ratamess. 2009).
"Breakdown sets require the performance of a set to MMF with a given load before immediately reducing the load and continuing repetitions to subsequent MMF. As such, this technique can allow MMF to be achieved in addition to potentially inducing greater fatigue-related stimuli. It is thought that this might maximize recruitment of both type II and type I MUs through use of both heavier and lighter loads thus allowing the combination of high muscular tension and inducing greater MU fatigue, metabolic stress, and ischemia because of extended time under tension" (Fisher. 2016).
In said study, the authors expected that reducing the load from set to set would allow those muscle fibers that have not reached a state of complete fatigue with higher loads to be eventually recruitment, as well. The expected consequence obviously is an augmentation of the subjects' adaptive response to exercise, one of which we have little scientific evidence, though:
"To date, there are few empirical research studies that have considered the use of BD training. Keogh et al. (24) and Goto et al. (2003) considered the acute effects of BD training on muscle activation and hormonal response, respectively. However, neither study provides evidence toward chronic adaptations. Goto et al. reported greater increases in growth hormone (GH) after the BD training protocol (sets of knee extension at 90% 1RM followed by a set at 50% 1RM) compared with a traditional RT protocol (sets of knee extension at 90% 1RM)" (Fisher. 2016).
Since Keogh et al. (24) used a variation of BD training whereby participants only performed a single repetition at a near-maximal load (95% 1RM) or starting with the 1RM as it was done in the Berger and Hardage study before reducing the load for each of 5 consecutive repetitions, the significance of their results for anyone doing "regular" drop sets / BD sets.

Figure 1: Strength and size gains with regular training (HS) and regular training plus a single set of low-intensity high rep RT after 5 high intensity, low rep sets (Goto. 2004).
A more realistic study was conducted by Goto et al. in 2004. In said study, the participants performed 6 weeks of an identical resistance exercise protocol and were then divided into either BD or traditional training groups. The traditional training group performed 5 sets of knee extension and leg press exercise 2 times per week at 90% 1RM with 3 minutes rest between exercise sets. The BD
training group performed the same protocol with an additional set performed 30 seconds after the fifth sets using 50% 1RM, where all sets in both groups were continued to a point of MMF.

The authors reported significantly greater results for leg press 1RM and maximal isokinetic torque (300 degree per second) and muscular endurance (repetitions to MMF at 30% of maximal voluntary contraction [MVC]) for the knee extension for the BD protocol compared with the traditional protocol.
SuppVersity Suggested (read more).
SuppVersity Suggested: "Training to Failure and Modifying Rest Times: Two Ways to Maximize Muscle Activity? Two Studies, Similar Implications" (read more). In a previous SuppVersity feature article, I have addressed not one, but two potentially highly relevant articles from the Journal of Strength and Conditioning Research (Looney. 2015) and the European Journal of Sport Science (Hiscock. 2015). What makes these papers interesting is that they tested the effect of commonly prescribed remedies to "bust a plateaus": (a) Training to failure and (b) modifying rep schemes and whether you fail or don't fail on every set.
However, as Fisher et al. point out, the "authors reported that the BD group showed greater increases in muscle cross-sectional area (CSA) of the thigh compared with the traditional group; however, this did not reach significance (p , 0.08)" (Fisher. 2016) - a non-significant advantage with a training protocol with higher volume? That's not exactly convincing, right?

The new study - What does it add to the existing research?

Therefore, Fisher et al. did another study with a randomized controlled trial design was adopted, with 3 experimental groups included. The effects of 3 RT interventions were examined in trained participants upon muscular performance and body composition.
Figure 2: Consort diagram showing how the study was designed (Fisher. 2016)
Participants were required to have had at least 6 months of RT experience (single-set training to MMF for multiple exercises including most major muscle groups, >2 times per week) and no medical condition for which RT is contraindicated to participate. Participants were then randomized using a computer randomization program to 1 of 3 groups: regular BD aka drop set training (n = 11), heavy-load breakdown (HLBD, n = 14), and  a control (CON, n = 11) group.
Putting the results into perspective: Every study has its strengths and weaknesses. For the study at hand, for example, the repetition volume standardization is both, a strength and a weakness: While it is meant to effectively isolates the effects of breakdown / dropsets (you can argue that it failed, because the total volume as reps x weight still differed, albeit not significantly), you could argue that doing more reps is what doing dropsets is all about. As the scientists point out, the mixed gender of the study population, and its uneven distribution across the three groups, as well as the low number of exercises and exercise-specific benefits (for the chest press the statistical analysis revealed p = 0.051, with effect sizes differing considerably between BD, HLBD, and CON groups - 1.22, 2.74, and 1.46, respectively) are other factors that may warrant further investigation in differently designed studies, before we can finally confirm that dropsets are another useless advanced training technique.
Participants were asked to refrain from any exercise away from the supervised sessions. Body composition was estimated using air displacement plethysmography (Bod Pod GS; Cosmed, Chicago, IL, USA) before and after working out twice per week for 12 weeks according to a protocol, Fisher et al. describe as follows:
"Each exercise was performed for one set (+ breakdown set in the BD group) per training session at a 2:4 repetition duration until MMF (i.e., when they reached a point of concentric failure during a repetition) to control for intensity of effort between groups. All participants performed 2 exercise sessions per week. The first of these, workout “A,” consisted of chest press, leg press, pull-down (MedX) overhead press, adductor, abductor (Nautilus Evo, Vancouver, WA, USA), abdominal flexion (MedX Core Ab Isolator), and lumbar extension (Roman chair using bodyweight or manual resistance; Hammer Strength, Rosemount, IL, USA). The second session, workout “B,” consisted of pecfly, pullover (Nautilus Evo), leg extension (MedX), dip, biceps curl (Nautilus Evo), seated calf raise (Hammer Strength), leg curl, and core torso rotation (MedX) resistance machines" (Fisher. 2016).
As usual, the weights were increased by 5%, once participants were able to perform more than 12 repetitions before achieving MMF.  The breakdown / dropsets were used for the chest press, leg press, and pulldown exercises in workout A only (e.g., the exercises that were tested). All other exercises were performed to MMF with a load permitting 8–12 repetitions.
  • BD group: For the chest press, leg press, and pull-down exercises, the BD group performed a single set of 8–12 repetitions to MMF and immediately reduced the load by ~30% and then continued performing repetitions to MMF. 
  • HLBD group: Using the same 3 exercises, the HLBD group used a heavier load permitting only ~4 repetitions; upon reaching MMF, they decreased the load by ~20% and continued performing repetitions to MMF and then repeated the BD reducing the load by a further 20% and performing repetitions to MMF. 
  • CON group: Subjects in the control group performed all exercises for a single set of 8–12 repetitions to MMF with no BD. 
As Fisher et al. point out, the "group protocols were chosen to allow parity between training load (the BD and CON groups both used the same relative load to begin; permitting 8–12 repetitions) and repetition volume (the HLBD and CON groups both performed a total of ~8 to 12 repetitions)" (Fisher. 2016)... and guess what: With identical load and repetition volume, the scientists found "no significant between-group [pre vs. post] differences" (Fisher. 2016) for change in absolute muscular
endurance for chest press, leg press, or pull-down exercises or for body composition changes.
Figure 3: Looking at the error bars will suffice to tell that there was no significant inter-group difference (Fisher. 2016).
In line with that, the effect sizes for absolute muscular endurance changes were large for all groups and exercises (0.86–2.74) - again, whithout significant inter-group differences.
Bottom line: As the authors point out, "[t]he present study supports previous research that the use of advanced training techniques stimulates no greater muscular adaptations when compared with
performing more simplified RT protocols to momentary muscular failure" (Fisher. 2016).

While the set volume was identical, the total volume (weight x reps) differed, albeit non-significantly, in favor of HLBD and CON (Fisher. 2016).
This is a hardly debatable result, but it may still be misleading: After all, the same standardization of initial loads and the repetition volume that is necessary to get reliable scientific information about the effects of dropsets / breakdown sets on their own, fails to represent the reason and effects of / for using drop sets in the real world: an increase in set volume (not total volume = weight x reps, see Figure to the right). Overall, it is thus not impossible that you may see the same improvements, Goto et al. observed in the previously discussed 2004 study. Eventually, however, this may be a result of an increased set volume, not the often talked about funky increase in muscle fiber recruitement | Comment on Facebook!
References:
  • Fisher, James, et al. "Evidence-based resistance training recommendations." Med Sport 15.3 (2011): 147-162.
  • Fisher, James, James Steele, and Dave Smith. "Evidence-based resistance training recommendations for muscular hypertrophy." Med Sport 17.4 (2013): 217-235.
  • Fisher, James Peter, et al. "The effects of pre-exhaustion, exercise order, and rest intervals in a full-body resistance training intervention." Applied Physiology, Nutrition, and Metabolism 39.11 (2014): 1265-1270.
  • Fisher, James Peter, et al. "The effects of breakdown set resistance training on muscular performance and body." (2015).
  • Giessing, Jürgen, et al. "The effects of low volume resistance training with and without advanced techniques in trained participants." J Sports Med Phys Fitness. Epub (2014).
  • Goto, Kazushige, et al. "Muscular adaptations to combinations of high-and low-intensity resistance exercises." The Journal of Strength & Conditioning Research 18.4 (2004): 730-737.
  • Ogborn, Dan, and Brad J. Schoenfeld. "The role of fiber types in muscle hypertrophy: Implications for loading strategies." Strength & Conditioning Journal 36.2 (2014): 20-25.
  • Ratamess, N. A., et al. "Progression models in resistance training for healthy adults [ACSM position stand]." Med Sci Sports Exerc 41.3 (2009): 687-708.
  • Sandee, Jungblut. "The correct interpretation of the size principle and it’s practical application to resistance training." Med Sport 13 (2009): 203-209.

Minggu, 24 April 2016

Discontinuing the Set When You Slow Down on Squats May Boost Strength Gains + Preserve MHC-IIX Fiber Percentage

You want to get rid of those tiny weights and squat big time? Maybe you should watch your squatting velocity... and no, I am not talking about slowing down - rather about keeping your rep speed.
While the headline may suggest that this is yet another article about time under tension, the "speed" I refer to in the headline is only indirectly related to the TUT concept. Rather than that, speed, in this case, refers to the velocity with which you squat... or, to be more precise, the magnitude of repetition velocity loss allowed in each set (20% vs 40%) and its effects on structural and functional adaptations in response to resistance training (RT).

Previous studies have shown that the degree of neuromuscular fatigue induced by RT protocols can be monitored by assessing the repetition velocity loss within a set (Sanchez-Medina. 2011).
Different velocity loss schemes may also be used as part of classic periodization schemes.

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In the study at hand, the scientists did thus use a novel, velocity-based approach to resistance training programming, in which the fixed number of repetitions you have to perform with a given load is replaced by two hitherto largely ignored, closely related variables:
  • the repetition’s mean velocity (how far are you squatting down and getting back up), which is intrinsically related to relative loading magnitude, and
  • the velocity loss to be allowed, expressed as a percent loss in mean velocity from the fastest (usually first) repetition of each exercise set.
In practice this means that you (a) can only select weights with which you can perform the exercise with perfect form at the given speed and (b) you will have to drop the bar, as soon as the prescribed percent velocity loss limit is exceeded - a velocity limit that was set to either 20% or 40% in a recent study from the Pablo de Olavide University (Pareja-Blanco. 2016).
Table 1: Descriptive characteristics of the velocity-based squat training program performed by both experimental groups | Data are mean SD. Only one exercise (full squat) was used in training (Pareja-Blanco. 2016).
The scientists recruited twenty-four young and healthy men (age 22.7 1.9 years, height 1.76 0.06 m, body mass 75.8 7.0 kg)m who volunteered to participate in this study. Their initial 1RM strength for the full (deep) squat (SQ) exercise was 106.2 +/- 13.0 kg (1.41 0.19 normalized per kg of body mass). All subjects were physically active sports science students with a RT experience ranging from 1.5 to 4 years (1–3 sessions/week) and were accustomed to performing the squat exercise with correct technique. The subjects trained twice a week (48–72 h apart) during 8-week for a total of 16 sessions. A progressive RT program which comprised only the squat as the sole exercise was used (Table 1).
"The two groups trained at the same relative loading magnitude (per centage of one-repetition maximum, %1RM) in each session but differed in the maximum percent velocity loss reached in each exercise set (20% vs 40%). As soon as the corresponding target velocity loss limit was exceeded, the set was terminated. Sessions were performed in a research laboratory under the direct supervision of the investigators, at the same time of day ( 1 h) for each subject and under controlled environmental conditions (20 °C and 60% humidity). Subjects were required not to engage in any other type of strenuous physical activity, exercise training, or sports competition for the duration of the present investigation. Both VL20 and VL40 groups were assessed on two occasions: 48 h before (Pre) and 72 h after (Post) the 8-week training intervention. Training compliance was 100% of all sessions for the subjects that completed the intervention" (Pareja-Blanco. 2016).
Pre- and post-training assessments included: magnetic resonance imaging, vastus lateralis biopsies for muscle cross-sectional area (CSA) and fiber type analyses, one-repetition maximum strength and full load-velocity squat profile, countermovement jump (CMJ), and 20-m sprint running - the analysis yielded the following results:
  • The VL20 group trained at a significantly faster mean velocity than those from VL40 (0.69 +/- 0.02 vs 0.58 +/- 0.03 m/s, respectively; P < 0.001), but did sign. less reps [VL40 performed more repetitions (P < 0.001) than VL20 (310.5 +/- 42.0 vs 185.9 +/- 22.2)]. 
  • The mean fastest repetition during each session (that which indicates the relative magnitude of the load being lifted) did not differ between groups (0.75 +/- 0.03 vs 0.76 +/- 0.01 m/s, for VL40 and VL20, respectively) and initial repetition velocities matched the expected target velocities for every training session. 
  • The VL40 group reached muscle failure during 27.0 +/-  4.2 sets (56.3% of total training sets), the VL20 group did not reach failure at all. 
  • Total work was significantly greater for VL40 compared to VL20 (200.6 +/- 47.1 vs 127.5 +/- 15.2 kJ, P < 0.001).
Now based on the often-heard and actually scientifically backed assumption that increases in total volume and training to failure are both conducive to strength gains, we should expect that the VL40 group saw greater increases in muscle size and 1RM strength. This was yet not the case. 
Figure 1: Rel. changes in selected neuromuscular performance variables from pre- to post-training for each group;
p-values indicate the significance of time x group effects, meaning only the inter-group difference in
counter-movement jump performance is statistically significant (Pareja-Blanco. 2016).
Instead, (1) VL20 resulted in similar squat strength gains as VL40, (2) VL20 resulted in greater improvements in CMJ (9.5% vs 3.5%, P < 0.05), and (3) both groups saw identical increases in mean fiber CSA.
Figure 2: Changes in muscle volume for: (a) Whole quadriceps femoris; (b) rectus femoris (RF); (c) vastus medialis (VM); and (d) vastus lateralis plus vastus intermedius (VL+VI | Pareja-Blanco. 2016).
And the above occured in spite of the fact that the VL20 performed 40% fewer repetitions and never reached failure. Can't be? Well, you're right, there's more to the story:"Although both groups increased mean fiber CSA and whole quadriceps muscle volume, VL40 training elicited a greater hypertrophy of vastus lateralis and intermedius than VL20" (Pareja-Blanco. 2016). 
Figure 3: Changes in muscle cross-sectional areas and muscle fiber types percentages, from pre- to post-training for each group, using myofibrillaro adenosine triphosphatase histochemestry; p-values indicate the significance of time x group effects, meaning only the MHC-IIX fiber reduction was sign. different between groups (Pareja-Blanco. 2016).
On the other hand, the VL40 group saw a not exactly strength conducive reduction of myosin heavy chain IIX percentage in the muscle - a change that did not occur in the VL20 group - quite obviously an "endurance" adaptation, the benefit / harm of which would be sport-dependent.
Mo, We, Fr - Sequence of Hypertrophy, Power & Strength Will Up Your Gains on the Big Three (Squat, Bench, Deadlift) / Squat, bench press, deadlift - All major three benefit from the right order in your daily undulating periodization program (DUP) - This is how it works... | learn more
Bottom line: Since this is the first study to probe the effect of two isoinertial RT programs differing in the magnitude of velocity loss experienced during each exercise set on muscle structure and performance, I believe it would be preliminary to draw any conclusions about training in general, but it is unquestionably intriguing that this new way of programming RT regimen in scientific studies did not confirm the classic "higher volume + train to failure = increased gains"-conundrum. Instead, it would appear that using a significant drop in your rep velocity (instead of voluntary failure) as a guide will produce similar size and marginally superior strength gains... at least in trained subjects for the squat exercise.

The latter limitation already reveals: We will need more research to determine how the rep velocity influences the adpatational response to exercise in other subjects, other exercises, training frequencies, intensities, other time-frames and so on and so forth | Comment!
References:
  • Pareja‐Blanco, F., et al. "Effects of velocity loss during resistance training on athletic performance, strength gains and muscle adaptations." Scandinavian Journal of Medicine & Science in Sports (2016).
  • Sanchez-Medina, Luis, and Juan José González-Badillo. "Velocity loss as an indicator of neuromuscular fatigue during resistance training." Med Sci Sports Exerc 43.9 (2011): 1725-1734.